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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
Tuesday, 02.23.2016, 02:06am
Nowell et al. report that chronic inflammation of the corneal epithelium activates β-catenin signalling through YAP/TAZ-dependent mechanotransduction, leading to epidermal differentiation on the ocular surface and corneal squamous cell metaplasia.
Reflections on immunological nomenclature: in praise of imperfection
Tuesday, 02.23.2016, 02:06am
Forging and amending nomenclature is a challenge at a time of growing complexity and plasticity. 
Solutions for quantifying P-value uncertainty and replication power
Friday, 02.19.2016, 12:17am
To characterize the uncertainty of the initial P value alone, we introduce P-value confidence intervals for the “true population P value” or π value, which we define as the value of P when parameter estimates equal their unknown population values
Ecology: Vegetation's responses to climate variability
Friday, 02.19.2016, 12:17am
Satellite data have allowed scientists to generate a quantitative model to assess the response rates of different ecosystems to climate variability. The index provides a tool for comparing regional sensitivity and resilience.
Apollo-NADP+: a spectrally tunable family of genetically encoded sensors for NADP+
Wednesday, 02.17.2016, 11:14pm
HomoFRET sensors based on G6PD homodimerization allow direct sensing of NADPH/NADP+ redox state in living cells. Spectrally tuning the Apollo-NADP+ sensor allows multiplex imaging for studies of oxidative stress in beta cells.
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
Wednesday, 02.17.2016, 11:14pm
Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.
  » Reflections on immunological nomenclature: in praise of imperfection
  » Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
  » The Author File: Jason W. Chin
  » Controlling spin relaxation with a cavity
  » Obama's cancer moonshot
  » Improving databases for human variation
  » Regeneration: Stem cells make the bowel nervous
  » Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe
  » Obama's cancer moonshot
  » Human keratinocytes have two interconvertible modes of proliferation


 
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High quality histologic services are crucial for determining study outcomes. http://www.allelebiotech.com/histology/

::| Hot News
Confidence and certainty: distinct probabilistic quantities for different goals
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Enabling direct fate conversion with network biology
High-density three-dimensional localization microscopy across large volumes
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Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
A saposin-lipoprotein nanoparticle system for membrane proteins
Conceptual and technical advances define a key moment for theoretical neuroscience
Points of View: Neural circuit diagrams
Stem cells in the limelight