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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
 
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
Tuesday, 09.18.2012, 11:03am
Human myocardial grafts meet physiological criteria for true heart regeneration, providing support for the continued development of hESC-based cardiac therapies for both mechanical and electrical repair.
Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA
Friday, 09.14.2012, 08:41am
The therapeutic promise of induced pluripotent stem cells (iPSCs) has spurred efforts to circumvent genome alteration when reprogramming somatic cells to pluripotency. We accelerated the mRNA reprogramming process through stepwise optimization of the RF cocktail and leveraged these kinetic gains to establish a feeder-free, xeno-free protocol which slashes the time, cost and effort involved in iPSC derivation.
Lineage conversion methodologies meet the reprogramming toolbox
Friday, 09.07.2012, 07:13am
Lineage conversion has recently attracted increasing attention as a potential alternative to the directed differentiation of pluripotent cells to obtain cells of a given lineage. Different means allowing for cell identity switch have been reported. Lineage conversion relied initially on the discovery of specific transcription factors generally enriched and characteristic of the target cell, and their forced expression in cells of a different fate. This approach has been successful in various cases, from cells of the hematopoietic systems to neurons and cardiomyocytes. Furthermore, recent reports have suggested the possibility of establishing a general lineage conversion approach bypassing pluripotency. This requires a first phase of epigenetic erasure achieved by short overexpression of the factors used to reprogram cells to a pluripotent state (such as a combination of Sox2, Klf4, c-Myc and Oct4), followed by exposure to specific developmental cues. Here we present these different direct conversion methodologies and discuss their potential as alternatives to using induced pluripotent stem cells and differentiation protocols to generate cell populations of a given fate.
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2
Monday, 08.20.2012, 10:59am
By day 4 after transduction with OSKM, two epigenetic modification factors necessary for iPSC generation, namely poly(ADP-ribose) polymerase-1 (Parp1) and ten-eleven translocation-2 (Tet2), are recruited to the Nanog and Esrrb loci.
Cross-talk between neural stem cells and immune cells: the key to better brain repair?
Friday, 08.17.2012, 01:43pm
Immune cells participating in CNS inflammation are now known to mediate both beneficial and detrimental effects. In this review, the authors examine the recently discovered bidirectional relationship between immune cells and neural stem cells and how these interactions may influence brain repair and provide new therapeutic targets.
What happens after you introduce OSKM to the cells?
Tuesday, 07.17.2012, 12:54pm
Mansour et al showed that β€œin mice and humans that the histoneH3methylated Lys 27(H3K27) demethylase Utx6–9 (also known as Kdm6a) regulates the efficient induction, rather than maintenance, of pluripotency.” 
  » Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
  » Stem cell research: Regulating translational application
  » Holding on to stemness
  » Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
  » Stem cell biology: Towards the reality of cell therapeutics
  » Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures
  » Making brown adipose tissues from RiPSCs
  » Changes in stem cells--a comprehensive analysis
  » An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
  » Large Intergenic Non-Coding RNAs (lincRNAs) Play Large Roles in Pluripotency


 
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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
http://www.allelebiotech.com/cell-models/
::| Hot News
Enabling direct fate conversion with network biology
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Stem cells in the limelight
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Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage