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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
 
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
Friday, 03.22.2013, 09:00am
Focal and segmental glomerulosclerosis, or renal scarring, is a debilitating disease. The identification of the molecular mechanisms of its initiation and progression has been limited, thus hampering the development of proper animal models. Dontscho Kerjaschki and his colleagues now report that microRNA-193a is elevated in human cases of the disease and that transgenic expression in mice is sufficient to cause the condition.
Stem cells: Anatomy of an ovarian cancer
Friday, 03.08.2013, 09:54am
Whether ovarian cancer originates in the ovary or the surrounding tissues is a focus of debate. Work in mice now shows that stem cells that replenish the ovarian surface epithelium can be the initiators of this cancer.
Roche and BioLamina start collaboration to develop novel cell culture systems
Wednesday, 03.06.2013, 01:37am

BioLamina, Stockholm, Sweden and Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the signing of a research and development agreement to jointly develop new cell culture systems for various applications, including stem cell research.

Stem Cells: A unifying theory for the crypt
Wednesday, 02.27.2013, 12:13pm
A long-standing ambiguity has been whether quiescent cells located in intestinal crypt structures are stem cells. The answer seems to be yes and no, depending on how one defines the term stem cell.
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
Monday, 02.11.2013, 10:17am
Molecular control of the pluripotent state is thought to reside in a core circuitry of master transcription factors including the homeodomain-containing protein NANOG, which has an essential role in establishing ground state pluripotency during somatic cell reprogramming. Whereas the genomic occupancy of NANOG has been extensively investigated, comparatively little is known about NANOG-associated proteins and their contribution to the NANOG-mediated reprogramming process. Using enhanced purification techniques and a stringent computational algorithm, we identify 27 high-confidence protein interaction partners of NANOG in mouse embryonic stem cells. These consist of 19 previously unknown partners of NANOG that have not been reported before, including the ten-eleven translocation (TET) family methylcytosine hydroxylase TET1. We confirm physical association of NANOG with TET1, and demonstrate that TET1, in synergy with NANOG, enhances the efficiency of reprogramming. We also find physical association and reprogramming synergy of TET2 with NANOG, and demonstrate that knockdown of TET2 abolishes the reprogramming synergy of NANOG with a catalytically deficient mutant of TET1. These results indicate that the physical interaction between NANOG and TET1/TET2 proteins facilitates reprogramming in a manner that is dependent on the catalytic activity of TET1/TET2. TET1 and NANOG co-occupy genomic loci of genes associated with both maintenance of pluripotency and lineage commitment in embryonic stem cells, and TET1 binding is reduced upon NANOG depletion. Co-expression of NANOG and TET1 increases 5-hydroxymethylcytosine levels at the top-ranked common target loci Esrrb and Oct4 (also called Pou5f1), resulting in priming of their expression before reprogramming to naive pluripotency. We propose that TET1 is recruited by NANOG to enhance the expression of a subset of key reprogramming target genes. These results provide an insight into the reprogramming mechanism of NANOG and uncover a new role for 5-methylcytosine hydroxylases in the establishment of naive pluripotency.
Cardiac stem cell therapies inch toward clinical litmus test
Tuesday, 01.22.2013, 10:10am
Upcoming phase 3 studies of adult/mesenchymal stem cell therapies in cardiac disease could provide definitive answers to the vexed question of whether these treatments can offer patients meaningful clinical benefits.
  » Characterization of pluripotent stem cells
  » Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells
  » Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells
  » Conversion of human fibroblasts to angioblast-like progenitor cells
  » Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
  » Generation of human induced pluripotent stem cells from urine samples
  » Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways
  » The functions of microRNAs in pluripotency and reprogramming
  » [Report] Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
  » Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury


 
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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
http://www.allelebiotech.com/cell-models/
::| Hot News
Enabling direct fate conversion with network biology
Stem cells in the limelight
Stem cells in the limelight
Regeneration: Stem cells make the bowel nervous
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage