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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
 
Metalloproteinases in mammary stem cell activity
Monday, 09.09.2013, 09:20am
Adult mammary stem cells remodel the mammary gland in development and pregnancy. The mammary stem cell population expands in response to extracellular signals such as Wnt.
Nuclear reprogramming and the cancer genome
Tuesday, 09.03.2013, 08:45pm
Three disciplines—cancer genomics, functional analysis of cancer cells and nuclear reprogramming—have come together to focus on the basic biology of cell commitment in our Nature Conference with the Ludwig Institute for Cancer Research held 25–27 September in Oxford, UK.
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Sunday, 08.04.2013, 12:20am
The combination of controlled three-dimensional assembly and electrical stimulation allows the maturation of stem cell–derived cardiomyocytes.
[Report] Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
Friday, 07.19.2013, 09:37am
A proof-of-principle study reports somatic reprogramming to the pluripotent state using small-molecule compounds.Authors: Pingping Hou, Yanqin Li, Xu Zhang, Chun Liu, Jingyang Guan, Honggang Li, Ting Zhao, Junqing Ye, Weifeng Yang, Kang Liu, Jian Ge, Jun Xu, Qiang Zhang, Yang Zhao, Hongkui Deng
Sequential addition of reprogramming factors improves efficiency
Monday, 07.08.2013, 01:30pm
Addition of a specific set of transcription factors reprograms somatic cell nuclei to a pluripotent state. Sequential addition of these factors, rather than the simultaneous exposure used in standard protocols, improves reprogramming efficiency. This sequential method favours a transition through a state with enhanced mesenchymal characteristics before driving an epithelial transformation on the way to the pluripotent state.

Note by AlleleNews: The main article cited in this News and Views used retrovirus to deliver the Yamanaka 4 factors on a timed schedule. It could have been more controlled if it were done with transient delivery vehicle such as mRNA.
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Friday, 07.05.2013, 08:01pm
The combination of controlled three-dimensional assembly and electrical stimulation allows the maturation of stem cell–derived cardiomyocytes.
  » Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
  » Stem cells: Changing one cell type into another
  » Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
  » Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs
  » Stem cells: Regulation by alternative splicing
  » Large non-coding RNA in pluripotency
  » Creating human ESCs by nucleus transfer
  » Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
  » Gene-pair expression signatures reveal lineage control
  » Glucose–TOR signalling reprograms the transcriptome and activates meristems


 
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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
http://www.allelebiotech.com/cell-models/
::| Hot News
Enabling direct fate conversion with network biology
Stem cells in the limelight
Stem cells in the limelight
Regeneration: Stem cells make the bowel nervous
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage