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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
 
Stem cell fate regulation by dynein motor protein Lis1
Thursday, 03.13.2014, 10:57am
Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor–regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.
Haematopoietic stem cells require a highly regulated protein synthesis rate
Tuesday, 03.11.2014, 05:34pm
Haematopoietic stem cells (HSCs) have a lower rate of protein synthesis in vivo than most other haematopoietic cells, and both increases and decreases in the rate of protein synthesis impair HSC function, demonstrating that HSC maintenance—and hence, cellular homeostasis—requires the rate of protein synthesis to be highly regulated.
Impact of genomic damage and ageing on stem cell function
Friday, 02.28.2014, 10:59am
In the second Review in our Genomic Instability series, Rudolph and colleagues discuss how the genomic damage that accumulates during ageing affects stem cell function through both cell-intrinsic and cell-extrinsic mechanisms.
Identification of small molecules that support human leukemia stem cell activity ex vivo
Thursday, 02.27.2014, 12:06pm
This paper reports conditions for the in vitro culture of human leukemia stem cells, which should enable basic studies as well as chemical screens on these cells.
In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators
Thursday, 02.20.2014, 01:03am
Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Fuchs and colleagues use a genome-wide survey to discover that Wnt effectors TCF3, TCF4 and Groucho (TLE) coordinately repress Wnt target genes. They find that although β-catenin is dispensable for HSFC viability and proliferation, it is essential to relieve this repression to initiate hair follicle fate during the hair regeneration cycle.
In situ identification of bipotent stem cells in the mammary gland
Monday, 01.27.2014, 12:38pm
Through the use of a novel three-dimensional imaging technique, used in conjunction with a multicolour reporter that allows lineage tracing and cell tracking of entire mammary ducts in vivo, bipotent stem cells are shown to have a central role in both puberty and long-term maintenance.
  » Italy blocks controversial stem cell therapy
  » Epigenetics, vitamin supplements and cellular reprogramming
  » Stem cells: The developing human brain—modeled in a dish
  » [Report] Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
  » Stem cells: The developing human brain—modeled in a dish
  » In vitro sperm production from mouse spermatogonial stem cell lines using an organ culture method
  » Starvation favors glioma stem cells
  » Starvation favors glioma stem cells
  » Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
  » Stem cells: Reprogramming in situ


 
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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
http://www.allelebiotech.com/cell-models/
::| Hot News
Enabling direct fate conversion with network biology
Stem cells in the limelight
Stem cells in the limelight
Regeneration: Stem cells make the bowel nervous
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage