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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
[Report] foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka
Thursday, 06.11.2015, 11:26am
Here we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm–egg fate decision in medaka fish.
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming
Wednesday, 06.10.2015, 11:14pm
Qin, Pei and colleagues report that autophagy is induced early during somatic cell reprogramming into induced pluripotent stem cells. mTORC1 and autophagy control reprogramming efficiency by modulating mitochondrial architecture and p62 levels.
Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells
Friday, 06.05.2015, 09:29pm
In this protocol, pluripotent stem cells are first differentiated into expandable cells resembling human mesoangioblasts; subsequently, transient MyoD induction drives differentiation into multinucleated myotubes.
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Friday, 05.29.2015, 10:13am
A method for 3D differentiation of human pluripotent stem cells yields brain cortical spheroids with functional neurons and astrocytes. The spheroids can be sliced for imaging and electrophysiological studies.
[Perspective] It’s about time for neural crest
Tuesday, 05.05.2015, 10:36am
In this week’s Science Express, Buitrago-Delgado et al. provide further support for this bold statement in demonstrating that neural crest cells uniquely retain pluripotent stem cell programming until later in development than the three classic germ layers.
Stem cells: slow and steady wins the race
Monday, 05.04.2015, 09:14pm
How are quiescent adult neural stem cells (NSCs) generated during development? A study now identifies a reserve population of p57-expressing, slowly dividing embryonic neural progenitors that later give rise to adult NSCs.
  » Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells
  » Dual role of YAP and TAZ in renewal of the intestinal epithelium
  » Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells
  » A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
  » Chronic variable stress activates hematopoietic stem cells
  » Chemically defined generation of human cardiomyocytes
  » Embryonic stem cell identity grounded in the embryo
  » Reprogramming goes through a primitive-streak-like state
  » Converging on neurodegenerative mechanisms
  » Identification of small molecules that support human leukemia stem cell activity ex vivo

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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
::| Hot News
Enabling direct fate conversion with network biology
Stem cells in the limelight
Stem cells in the limelight
Regeneration: Stem cells make the bowel nervous
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage