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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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iPSC MSC ESC Differentiation
 
 
Enabling direct fate conversion with network biology
Tuesday, 03.22.2016, 06:00am

Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.

 

Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes
Tuesday, 03.22.2016, 06:00am
Analysis of SLOS patient-derived iPSCs reveals that cellular accumulation of the cholesterol precursor 7DHC, rather than cholesterol deficiency, causes dysregulation of Wnt/β-catenin signaling and aberrant neural differentiation.
Biomedicine: Visionary stem-cell therapies
Friday, 03.11.2016, 12:59am
Stem-cell engineering has allowed successful cornea transplantations in rabbits and the regeneration of transparent lens tissue in children, demonstrating the therapeutic potential of this approach.
Stem cells in the limelight
Tuesday, 03.01.2016, 02:02am
Stem cell biology has emerged as one of the most exciting areas of basic and biomedical research. This month, we launch a series of specially commissioned articles that discuss recent advances and challenges in this field.
Stem cells in the limelight
Friday, 02.26.2016, 11:09pm
Stem cell biology has emerged as one of the most exciting areas of basic and biomedical research. This month, we launch a series of specially commissioned articles that discuss recent advances and challenges in this field.
Regeneration: Stem cells make the bowel nervous
Friday, 02.12.2016, 01:42am
In Hirschsprung disease, the enteric nervous system (ENS) is missing from the distal bowel. It emerges that postnatal transplantation of stem-cell-derived ENS precursors can prevent death in a mouse model of the disease.
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Friday, 11.20.2015, 01:01am
Dystrophin is expressed in muscle stem cells, in which it regulates their cell division and proper repopulation.
  » Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
  » Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
  » Generation of stomach tissue from mouse embryonic stem cells
  » Hepatic progenitor cells of biliary origin with liver repopulation capacity
  » Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
  » XBP1, a determinant of the eosinophil lineage
  » Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells
  » Beta-cell regeneration from vimentin+/MafB+ cells after STZ-induced extreme beta-cell ablation
  » Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells
  » [Report] foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka


 
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Allele Biotech's DNA-free, feeder-free, xeno-free mRNA reprogramming method is being applied to human clinical programs. Start your iPSC system right from the start!
http://www.allelebiotech.com/cell-models/
::| Hot News
Enabling direct fate conversion with network biology
Stem cells in the limelight
Stem cells in the limelight
Regeneration: Stem cells make the bowel nervous
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Generation of stomach tissue from mouse embryonic stem cells
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
XBP1, a determinant of the eosinophil lineage