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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Using single cell technologies for functional studies
Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance
Wednesday, 04.25.2012, 01:29pm
The adipocyte-derived hormone leptin acts on the brain to signal the long-term status of energy balance in the body. Martin Myers and his colleagues narrow down the population of neurons in the brain that actuate leptin's effects on food intake, and thus systemic energy balance, to a relatively small percentage of Nos1+ cells in the hypothalamus.
The role of ATM in response to metformin treatment and activation of AMPK
Tuesday, 04.17.2012, 09:46am
ATM, encoding a member of the phosphatidylinositol 3/phosphatidylinositol 4 (PI3/PI4)-kinase family, was the causative gene due to its reported function of anti-diabetic drug metformin
Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma
Tuesday, 04.10.2012, 08:49pm
VSV-expressed cDNA libraries can be used to identify tumor rejection antigens that can cooperate to induce anti-tumor responses.
The role of ATM in response to metformin treatment and activation of AMPK
Thursday, 04.05.2012, 10:13am
Is ATM, encoding a member of the phosphatidylinositol 3/phosphatidylinositol 4 (PI3/PI4)-kinase family, the causative gene of anti-diabetic drug metformin?
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Monday, 04.02.2012, 04:09pm
Downregulation of the glucose transporter GLUT4 in adipose tissue occurs early in the development of type 2 diabetes; here GLUT4-mediated glucose uptake is shown to induce a novel form of the transcription factor ChREBP, which regulates de novo lipogenesis and systemic glucose metabolism.
Urocortin 3 as marker for mature beta cells
Monday, 03.12.2012, 11:07pm
Useful for screening for iPSC-derived beta cells for use in diabetic patients.
  » GPR-120 is a faulty fat sensor, as shown in mouse model and confirmed in human sequencing data
  » Weight regain after weight loss linked to special alleles
  » Pancreatic Islet Cells Express Serotonergic Genes in Mice
  » An Activating Mutation of AKT2 and Human Hypoglycemia
  » Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1
  » Surprise finding of mutations in multiple RNA splicing factors in myeloid neoplasms by whole-exome sequencing
  » A natural antagonist of TNFa with implications in treating arthritis
  » Scientists have found more than 30 new gene variations linked to obesity
  » From Nature Biotechnology: SBIR grants wax
  » Genome-wide association study (GWAS) of metabolic traits identified metabolically relevant enzymes or carriers.

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High quality histologic services are crucial for determining study outcomes.

::| Hot News
Highly multiplexed simultaneous detection of RNAs and proteins in single cells
Robust enumeration of cell subsets from tissue expression profiles
Evolution: Fitness tracking for adapting populations
Targeting cells with single vectors using multiple-feature Boolean logic
Single-cell western blotting
[Report] Highly Multiplexed Subcellular RNA Sequencing in Situ
Determining cell division symmetry through the dissection of dividing cells using single-cell expression analysis
Single-cell technologies for monitoring immune systems
Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior
Quantitative assessment of single-cell RNA-sequencing methods