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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Using single cell technologies for functional studies
Single cell techniques isolated resident T cells in asymptomatic Herpes infection
Thursday, 05.09.2013, 11:12am
Resident Tcells are oligoclonal with diverse usage of TCR variable-β genes, which differ from those commonly described for mucosa-associated invariant Tcells and natural killer Tcells.
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
Wednesday, 04.24.2013, 10:13am
Brown adipose tissue (BAT) burns, rather than stores, energy and has thus been explored as a way to combat obesity. Aaron Cypess and his colleagues isolate neck fat from adult humans and show that BAT exists in this region, define its anatomical localization in the neck relative to white adipose tissue and demonstrate that it is functional.
Barcoding cells using cell-surface programmable DNA-binding domains
Friday, 03.22.2013, 09:00am
Surface expression of zinc-finger proteins coupled with double-stranded DNA probes permits programmable labeling and capture of subsets of cells in heterogenous populations.
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
Wednesday, 02.27.2013, 12:13pm
Alan Saltiel and his colleagues report that the approved drug amlexanox, currently used to treat asthma and canker sores, is a relatively specific inhibitor of the noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) and that it improves metabolic disease in mouse genetic and dietary models of obesity. These results suggest this drug may be repurposed to treat obesity and insulin resistance.
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
Wednesday, 02.13.2013, 12:05pm
TNF-α suppresses regulatory T (Treg) cell function, however the mechanism remains unclear. Here Jingwu Z Zhang and colleagues find that in activated T cells, phosphorylation of FOXP3 promotes its transcriptional activity. TNF-α induces protein phosphatase 1 expression, leading to dephosphorylation of FOXP3 and inhibition of Treg cell function. In individuals with rheumatoid arthritis, TNF-α–specific antibody treatment restores Treg cell activity and FOXP3 phosphorylation, suggesting that post-translational modifications, including phosphorylation, regulate FOXP3 activity and Treg cell–mediated suppression.
Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity
Wednesday, 02.13.2013, 12:05pm
Toll-like receptors (TLRs) are traditionally associated with immune-mediated host defense. Here, we ascribe a novel extra-immune, hypothalamic-associated function to TLR2, a TLR-family member known to recognize lipid components, in the protection against obesity. We found that TLR2-deficient mice exhibited mature-onset obesity and susceptibility to high-fat diet (HFD)-induced weight gain, via modulation of food intake. Age-related obesity was still evident in chimeric mice, carrying comparable TLR2+ immune cells, suggesting a non-hematopoietic-related involvement of this receptor. TLR2 was up-regulated with age or HFD in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus, a brain area participating in central-metabolic regulation, possibly modulating the hypothalamic-anorexigenic peptide, α-melanocyte-stimulating hormone (α-MSH). Direct activation of TLR2 in a hypothalamic-neuronal cell-line via its known ligands, further supports its capacity to mediate non-immune related metabolic regulation. Thus, our findings identify TLR2 expressed by hypothalamic neurons as a potential novel regulator of age-related weight gain and energy expenditure.
  » Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
  » Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
  » [Report] JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
  » Neurodevelopmental disorders: Signalling pathways of fragile X syndrome
  » [Report] JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
  » Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
  » Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals
  » Feeder-Free Derivation of Human Induced Pluripotent Stem Cells with Messenger RNA
  » Speckle-free laser imaging using random laser illumination
  » An optimized two-finger archive for ZFN-mediated gene targeting

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High quality histologic services are crucial for determining study outcomes.

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Highly multiplexed simultaneous detection of RNAs and proteins in single cells
Robust enumeration of cell subsets from tissue expression profiles
Evolution: Fitness tracking for adapting populations
Targeting cells with single vectors using multiple-feature Boolean logic
Single-cell western blotting
[Report] Highly Multiplexed Subcellular RNA Sequencing in Situ
Determining cell division symmetry through the dissection of dividing cells using single-cell expression analysis
Single-cell technologies for monitoring immune systems
Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior
Quantitative assessment of single-cell RNA-sequencing methods