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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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A saposin-lipoprotein nanoparticle system for membrane proteins
Thursday, 03.17.2016, 01:09am

A saposin protein–lipid nanoparticle system stabilizes diverse, fragile membrane proteins in a lipid environment for structural and functional studies.

 

Subverting misconceptions about radiation therapy
Thursday, 03.24.2016, 06:08am
Evidence is emerging that local radiation therapy can convert a tumor into an individualized cancer vaccine in a setting of otherwise ineffective immunotherapy and can work in concert with immunotherapy to control the primary tumor and metastasis outside the radiation field.
Using goal-driven deep learning models to understand sensory cortex
Wednesday, 03.23.2016, 05:06am
Recent computational neuroscience developments have used deep neural networks to model neural responses in higher visual areas. This Perspective describes key algorithmic underpinnings in computer vision and artificial intelligence that have contributed to this progress and outlines how deep networks could drive future improvements in understanding sensory cortical processing.
R-process enrichment from a single event in an ancient dwarf galaxy
Tuesday, 03.22.2016, 06:00am
Elements heavier than zinc are synthesized through the rapid (r) and slow (s) neutron-capture processes. This implies that a single, rare event produced the r-process material in Reticulum II. The r-process yield and event rate are incompatible with the source being ordinary core-collapse supernovae, but consistent with other possible sources, such as neutron star mergers.
Building functional networks of spiking model neurons
Monday, 03.21.2016, 04:47am
The networks used by computer scientists and by modelers in neuroscience frequently consider unit activities as continuous. Neurons, however, com­municate primarily through discontinuous spiking. This Perspective offers a unifying view of the current methods for transferring our ability to construct functional networks from continuous to more realistic spiking network models.
Conceptual and technical advances define a key moment for theoretical neuroscience
Friday, 03.18.2016, 09:44pm
Theoretical approaches have long shaped neuroscience, but current needs for theory are elevated and prospects for advancement are bright. Advances in measuring and manipulating neurons demand new models and analyses to guide interpretation. Advances in theoretical neuroscience offer new insights into how signals evolve across areas and new approaches for connecting population activity with behavior. These advances point to a global understanding of brain function based on a hybrid of diverse approaches.
Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury
Wednesday, 03.16.2016, 12:12am
In a rat model of spinal cord injury, calpain-dependent cleavage of motoneuron sodium channels can be pharmacologically targeted to achieve long-lasting amelioration of spasticity.
  » Inferring causal molecular networks: empirical assessment through a community-based effort
  » Focus on neural computation and theory
  » Analysis of computational footprinting methods for DNase sequencing experiments
  » The Author File: Markus Sauer
  » The power of disagreement
  » Peer review in the cloud
  » Highly multiplexed simultaneous detection of RNAs and proteins in single cells
  » Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
  » Reflections on immunological nomenclature: in praise of imperfection
  » Solutions for quantifying P-value uncertainty and replication power


 
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High quality histologic services are crucial for determining study outcomes. http://www.allelebiotech.com/histology/

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A saposin-lipoprotein nanoparticle system for membrane proteins
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Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue