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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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RNA, RNAi, and miRNA Updates
 
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
Wednesday, 06.20.2012, 09:45am
Temporal lobe epilepsy (TLE) is linked to neuron death in the hippocampus. Now David Henshall and colleagues show that miR-134 is upregulated in humans with TLE and in an experimental epilepsy model in mice. Decreasing miR-134 before induction of epilepsy in mice reduces neuron death and the generation of spontaneous seizures.
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
Wednesday, 06.13.2012, 10:08am
Temporal lobe epilepsy (TLE) is linked to neuron death in the hippocampus. Now David Henshall and colleagues show that miR-134 is upregulated in humans with TLE and in an experimental epilepsy model in mice. Decreasing miR-134 before induction of epilepsy in mice reduces neuron death and the generation of spontaneous seizures.
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
Wednesday, 06.06.2012, 08:20am
Several microRNAs have been identified that affect lymphocyte effector function and contribute toautoimmune inflammatory disease. Here Youcun Qian and his colleagues find that interleukin-17 (IL-17) suppresses miR-23b expression in nonimmune cells present in inflammatory lesions from individuals with rheumatoid arthritis, systemic lupus erythematosus or multiple sclerosis and in the respective mouse models. MiR-23b targets several signaling molecules downstream of IL-17, TNF-α and IL-1β signaling, thereby suppressing proinflammatory cytokine expression and inhibiting autoimmune pathogenesis in vivo.
RNAi patent win
Thursday, 03.15.2012, 10:44am
The new patent awarded to Plant Bioscience Limited (PBL) of Norwich for discoveries in plants made by David Baulcombe, University of Cambridge, and Andrew Hamilton, University of Glasgow, is likely to affect ongoing industrial research,
Prokaryotic RNAi
Tuesday, 03.13.2012, 02:04pm
By providing a 30-base-pair sequence complementary to any target, Hale et al. showed that the bacterial immune system could be harnessed to do something like eukaryotic RN
Secreted miRNAs mediate cell-cell communication
Sunday, 03.11.2012, 10:05pm
Secreted vesicles carrying miRNAs can mediate endothelial cells - vascular smooth muscle cells communication as a newly identified signaling route.
  » miRNA playing double roles in metastasis
  » Toward the blood-borne miRNome of human diseases
  » Epigenetic Licensing of Germline Gene Expression by Maternal RNA in C. elegans
  » miR-449 microRNAs are evolutionarily conserved regulators of the Delta/Notch pathway
  » How the core RNAi pathway is regulated throughout the cell cycle
  » miRNA in DNA damage response
  » Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
  » MicroRNA-132 is identified as a stimulator of neovascularization
  » Fruitless chirping in the night
  » Intronic miRNA and host gene coordinate to regulate biological process (cholesterol hoemostasis)


 
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::| Hot News
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
miRWalk2.0: a comprehensive atlas of microRNA-target interactions
MIR137: big impacts from small changes
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy