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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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RNA, RNAi, and miRNA Updates
 
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
Friday, 07.18.2014, 01:42pm
This protocol describes an RNAi-based high-throughput screening strategy for determining genetic interactions between pairs of mammalian genes; the information obtained is then used to construct genetic interaction maps.
Tobacco rattle virus–based virus-induced gene silencing in Nicotiana benthamiana
Monday, 06.09.2014, 09:46am
This Protocol describes how to downregulate specific plant genes using tobacco rattle virus virus-induced gene silencing (TRV-VIGS). The method can be used in a range of plants, but N. benthamiana is used here as an example.
Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy
Tuesday, 04.22.2014, 09:10am
The levels of miR-423-3p and miR-296-5p were correlated with the activity of caspase-3, an apoptosis indicator. Additionally, the loading of miR-423-3p was increased in RNA-induced silencing complex whilst caspase-6, a target of miR-423-3p, was reduced in chronic TLE rats.
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Thursday, 04.10.2014, 12:41pm
Atherosclerotic lesions develop preferentially at sites of disturbed blood flow. As shown by Christian Weber and his coworkers, this predilection stems from effects of disturbed blood flow on endothelial expression of the microRNA miR-126-5p, which maintains the proliferative reserve of endothelial cells through repression of the Notch pathway inhibitor Dlk1.
Markets, venture investors and big pharma interest in RNAi soars
Tuesday, 03.25.2014, 08:43am
Sanofi/Genzyme's $700-million equity investment in neighbor Alnylam Pharmaceuticals on January 13, and Watertown, Massachusetts–based Dicerna Pharmaceuticals' initial public offering (IPO), which closed on February 4 raising $92.9 million.
Markets, venture investors and big pharma interest in RNAi soars
Monday, 03.24.2014, 10:49pm
Massachusetts–based Sanofi/Genzyme's $700-million equity investment in neighbor Alnylam Pharmaceuticals on January 13, and Watertown, Massachusetts–based Dicerna Pharmaceuticals' initial public offering (IPO), which closed on February 4 raising $92.9 million.
  » Is this really the RNAissance?
  » MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
  » Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process
  » The evolution of lncRNA repertoires and expression patterns in tetrapods
  » Stable RNA interference rules for silencing
  » Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model
  » Production of highly potent recombinant siRNAs in Escherichia coli
  » A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
  » Fabrication of pRNA nanoparticles to deliver therapeutic RNAs and bioactive compounds into tumor cells
  » First microRNA mimic enters clinic


 
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::| Hot News
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
miRWalk2.0: a comprehensive atlas of microRNA-target interactions
MIR137: big impacts from small changes
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy