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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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RNA, RNAi, and miRNA Updates
 
 
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Wednesday, 01.06.2016, 11:40am

This virus-free approach for mRNA knockdown in vivo uses the siRNA carrier peptide protamine, chemically coupled to a cell surface receptor internalizing antibodies via sulfo-SMCC, to provide protection and guidance for the targeted application of siRNA.

 

Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Tuesday, 12.15.2015, 01:03am
This virus-free approach for mRNA knockdown in vivo uses the siRNA carrier peptide protamine, chemically coupled to a cell surface receptor internalizing antibodies via sulfo-SMCC, to provide protection and guidance for the targeted application of siRNA.
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
Friday, 10.09.2015, 12:23am
MicroRNA-148a, whose expression is regulated by the transcription factor SREBP1c, controls LDL and HDL metabolism through direct targeting of the genes encoding the LDL receptor and the cholesterol transporter ABCA1.
miRWalk2.0: a comprehensive atlas of microRNA-target interactions
Tuesday, 08.18.2015, 05:36pm

miRWalk2.0 (http://zmf.umm.uni-heidelberg.de/mirwalk2) is a comprehensive archive, supplying the largest available collection of predicted and experimentally verified microRNA (miRNA)-target interactions (~949 million)

MIR137: big impacts from small changes
Monday, 07.27.2015, 11:57am
Schizophrenia-linked single nucleotide polymorphisms in MIR137 alter expression of miR-137 in neurons. Abnormal expression of miR-137 affects vesicle release at presynaptic terminals and in turn alters hippocampal functioning.
Retraction: HMGA2 functions as a competing endogenous RNA to promote lung cancer progression
Thursday, 06.11.2015, 11:25am
In this Letter, we reported that Hmga2 promotes lung cancer progression in mouse and human cells by operating as a competing endogenous RNA for the let-7 microRNA family.
Plant biology: Coding in non-coding RNAs
Tuesday, 03.31.2015, 12:47pm
The discovery of peptides encoded by what were thought to be non-coding – or 'junk' – regions of precursors to microRNA sequences reveals a new layer of gene regulation. These sequences may not be junk, after all.
  » LincRNA signatures in human lymphocytes
  » Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate
  » Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
  » RNA switch at enhancers
  » RNA switch at enhancers
  » Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer
  » Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
  » RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)
  » Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
  » Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps


 
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::| Hot News
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
miRWalk2.0: a comprehensive atlas of microRNA-target interactions
MIR137: big impacts from small changes
Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate
Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy