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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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NexGen Sequencing, Epigenetics, and Editing
Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA
Monday, 09.08.2014, 10:13am
MAGE is a rapid in vivo method for introducing mutations into E. coli genomes. Libraries of synthetic ssDNA are used in iterative MAGE cycles to target multiple genomic sites. About five cycles can be carried out by one person in one day.
Evolutionary biology: Radiating genomes
Thursday, 09.04.2014, 10:59pm
Genome sequences and gene-expression data from representatives of five distinct lineages of African cichlid fish reveal signatures of the genomic changes that underlie the astounding cichlid diversity seen today.
Cancer gene discovery goes mobile
Thursday, 09.04.2014, 10:59pm
A new study describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this system in combination with cancer genome data to define new genes and pathways involved in sarcoma development. Gene discovery in this way suggests that we are far from a complete catalog of cancer drivers.
Proteomics: The human proteome takes the spotlight
Thursday, 07.24.2014, 12:59pm
Two papers report mass spectrometry–based draft maps of the human proteome and provide broadly accessible resources.
Isolation of rare recombinants without using selectable markers for one-step seamless BAC mutagenesis
Monday, 07.21.2014, 09:33am
Application of the founder principle from population genetics to variant selection after recombineering allows the isolation of rare unselected recombinants.
The complex domestication history of the common bean
Thursday, 07.17.2014, 09:57am
A new study reports the genome of common bean (Phaseolus vulgaris) and genome-wide resequencing data from both wild and domesticated accessions. These data confirm that common bean was domesticated at least twice, in Mesoamerica and South America, and also provide a framework to identify genes that contributed to the phenotypic changes associated with domestication.
  » First CRISPR-Cas patent opens race to stake out intellectual property
  » Wrong place, wrong time: ectopic progenitors cause cortical heterotopias
  » Comprehensive analysis of RNA-protein interactions by high-throughput sequencing–RNA affinity profiling
  » Sequencing: The big RNA picture
  » Epigenetics: Keeping one's sex
  » Global optimization of somatic variant identification in cancer genomes with a global community challenge
  » Targeted sequencing for gene discovery and quantification using RNA CaptureSeq
  » Global optimization of somatic variant identification in cancer genomes with a global community challenge
  » Genome editing for all
  » Targeted sequencing for gene discovery and quantification using RNA CaptureSeq

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::| Hot News
Analysis of five years of controlled access and data sharing compliance at the International Cancer Genome Consortium
Analysis of computational footprinting methods for DNase sequencing experiments
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
Co-occurrence of MYC amplification and TP53 mutations in human cancer
Quantification of private information leakage from phenotype-genotype data: linking attacks
Improving databases for human variation
A diamond in the ruff
Microbiomes: Curating communities from plants
Small island, big genetic discoveries
TARDIS, a targeted RNA directional sequencing method for rare RNA discovery