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Tuesday, 01.23.2018, 02:54pm (GMT-7)
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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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NexGen Sequencing, Epigenetics, and Editing
 
Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display
Wednesday, 06.03.2015, 10:50am
CRISPR-Display is a modular and flexible platform that targets natural or synthetic noncoding RNA domains to specific genomic loci for functional studies and synthetic biology.
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
Thursday, 05.07.2015, 10:56am
A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients.
Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing
Wednesday, 04.29.2015, 08:52am
The protocol by Guo et al. for single-cell reduced-representation bisulfite sequencing (scRRBS) enables methylation profiling of individual genomes. Single-cell methods help elucidate levels of variation between individual cells within a group.
Letters from Iceland
Tuesday, 04.28.2015, 12:43pm
The largest-ever set of human genomes from a single population and the consequent insights into mutation, evolution, gene function and disease predisposition are reported in four linked papers.
A vision and a prescription for big data–enabled medicine
Wednesday, 04.22.2015, 09:14am
Leveraging '-Omic' and sensor technologies technologies in clinical decision making will help to bring about the long-heralded personalization of medicine.
Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing
Wednesday, 04.15.2015, 08:07pm
The protocol by Guo et al. for single-cell reduced-representation bisulfite sequencing (scRRBS) enables methylation profiling of individual genomes. Single-cell methods help elucidate levels of variation between individual cells within a group.
  » DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
  » Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing
  » DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
  » Identification of active transcriptional regulatory elements from GRO-seq data
  » Mapping the epigenome
  » [Research Article] Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
  » Genome-wide profiling of DNA methylation provides insights into epigenetic regulation of fungal development in a plant pathogenic fungus, Magnaporthe oryzae
  » Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
  » Evolution of Darwin’s finches and their beaks revealed by genome sequencing
  » Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells


 
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::| Hot News
Analysis of five years of controlled access and data sharing compliance at the International Cancer Genome Consortium
Analysis of computational footprinting methods for DNase sequencing experiments
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
Co-occurrence of MYC amplification and TP53 mutations in human cancer
Quantification of private information leakage from phenotype-genotype data: linking attacks
Improving databases for human variation
A diamond in the ruff
Microbiomes: Curating communities from plants
Small island, big genetic discoveries
TARDIS, a targeted RNA directional sequencing method for rare RNA discovery