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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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NexGen Sequencing, Epigenetics, and Editing
Comparing the performance of biomedical clustering methods
Monday, 09.21.2015, 09:23pm
This analysis compares 13 clustering methods on 24 data sets using the freely accessibleClustEval platform and presents guidelines for how to choose tools and set parameters for clustering biomedical data.
Genomics is rapidly advancing precision medicine for immunological disorders
Friday, 09.18.2015, 10:34am
Advances in human genomics, when validated functionally, can lead to new insights into how the immune system works. Notably, previously unknown mechanisms revealed by genomics can lead to the development of precision medicine unanticipated on the basis of phenotype alone.
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
Thursday, 09.17.2015, 03:13pm
Two studies demonstrate that the methyltransferase KMT2D, which is recurrently mutated in several types of human B cell lymphoma, suppresses tumorigenesis by altering the epigenetic landscape of B cells; Kmt2d deletion in mice perturbs normal B cell development.
The UK10K project identifies rare variants in health and disease
Tuesday, 09.15.2015, 05:14pm
Low read depth sequencing of whole genomes and high read depth exomes of nearly 10,000 extensively phenotyped individuals are combined to help characterize novel sequence variants. 
Building a staircase to precision medicine for biliary tract cancer
Thursday, 09.10.2015, 10:24pm
A new study has conducted a comprehensive exome and transcriptome analysis of a large number of intrahepatic, perihilar and distal cholangiocarcinomas and gallbladder cancers in Japanese patients. This study identifies many new alterations, confirms genetic differences in these distinct subtypes of biliary tract cancer and demonstrates that approximately 40% of described genetic aberrations are potentially targetable.
Genetic differential calculus
Thursday, 09.03.2015, 10:55pm
High-throughput analysis of the phenotypes of mouse genetic knockouts presents several challenges, such as systematic measurement biases that can vary with time. A report from the EUMODIC consortium presents data from 320 genetic knockouts generated using standardized phenotyping pipelines and new statistical analyses aimed at increasing reproducibility across centers.
  » Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
  » Marshaling the Variome
  » Genetic variation links creativity to psychiatric disorders
  » Innate immune memory: a paradigm shift in understanding host defense
  » The European Genome-phenome Archive of human data consented for biomedical research
  » The European Genome-phenome Archive of human data consented for biomedical research
  » Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
  » Subclonal diversification of primary breast cancer revealed by multiregion sequencing
  » Subclonal diversification of primary breast cancer revealed by multiregion sequencing
  » The coming era of human phenotyping

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::| Hot News
Analysis of five years of controlled access and data sharing compliance at the International Cancer Genome Consortium
Analysis of computational footprinting methods for DNase sequencing experiments
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
Co-occurrence of MYC amplification and TP53 mutations in human cancer
Quantification of private information leakage from phenotype-genotype data: linking attacks
Improving databases for human variation
A diamond in the ruff
Microbiomes: Curating communities from plants
Small island, big genetic discoveries
TARDIS, a targeted RNA directional sequencing method for rare RNA discovery