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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Immune systems, T cell Therapy, stem cell therapy
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
Tuesday, 12.16.2014, 11:25am
We show here that memory CD4+ T cell survival is impaired in the absence of the Notch signaling protein known as recombination signal binding protein for immunoglobulin κ J region (Rbpj).
Developers seek to finetune toxicity of T-cell therapies
Thursday, 12.11.2014, 10:39am
Companies are developing a variety of low- and high-tech strategies to mitigate the effects of massive cytokine release—from a molecular 'dimmer switch' to better hospital protocols for anticipating the likelihood of severe toxicity.
Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes
Thursday, 11.13.2014, 11:10pm
Immune complexes from mouse models of systemic lupus erythematosus and from humans with the disease promote dendritic cell migration in vivo.
Landmark approvals in idiopathic pulmonary fibrosis
Tuesday, 11.11.2014, 06:01pm
The lung fibrosis field, buoyed by the first tangible if not stellar results in decades, is more active and upbeat than ever.
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Tuesday, 10.28.2014, 02:18pm
T-cell immunoglobulin domain and mucin domain-3 (TIM-3, also known as HAVCR2) is an activation-induced inhibitory molecule involved in tolerance and shown to induce T-cell exhaustion in chronic viral infection and cancers. Under some conditions, TIM-3 expression has also been shown to be stimulatory. Considering that TIM-3, like cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1), is being targeted for cancer immunotherapy, it is important to identify the circumstances under which TIM-3 can inhibit and activate T-cell responses. Here we show that TIM-3 is co-expressed and forms a heterodimer with carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on activated T cells and involved in T-cell inhibition.
Time to cast a larger net
Wednesday, 10.22.2014, 12:41pm
Neutrophils sense the size of microbial targets and respond via 'NETosis' when targets are too big to internalize and contain via phagocytosis.
  » Neutrophils worm their way into macrophage long-term memory
  » Clonal dynamics of native haematopoiesis
  » Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges
  » Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges
  » Integrative biology of T cell activation
  » First PD-1 inhibitor breezes across finish line
  » Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge
  » Integrative biology of T cell activation
  » [Report] A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
  » Integrative biology of T cell activation

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::| Hot News
Stem cells in the limelight
The genomic landscape of adult T cell leukemia/lymphoma
Reversed-polarity Treg cell TCRs provide a shock
Reversed-polarity Treg cell TCRs provide a shock
Subversion of anticancer immunosurveillance by radiotherapy
[Report] Genomic correlates of response to CTLA4 blockade in metastatic melanoma
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
CD8+ T cell diversification by asymmetric cell division
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
DPP4 in anti-tumor immunity: going beyond the enzyme