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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Immune systems, T cell Therapy, stem cell therapy
 
XBP1, a determinant of the eosinophil lineage
Wednesday, 07.29.2015, 08:50pm
Targeted deletion of the transcription factor XBP1 in hematopoietic stem cells selectively prevents eosinophil maturation in the bone marrow without affecting other lineages of the immune system.
DPP4 in anti-tumor immunity: going beyond the enzyme
Friday, 07.24.2015, 03:27pm
Inhibition of the dipeptidylpeptidase DPP4 (CD26) enhances chemokine CXCL10–mediated infiltration of lymphocytes into the tumor parenchyma, which results in diminished tumor growth.
[Report] T cell help controls the speed of the cell cycle in germinal center B cells
Thursday, 07.16.2015, 10:34pm
Genome sequencing and single-molecule analyses revealed that T cell help shortens S phase by regulating replication fork progression while preserving the relative order of replication origin activation.
First oncolytic virus edges towards approval in surprise vote
Thursday, 06.25.2015, 04:16am
Amgen's T-Vec (talimogene laherparepvec) is set to become the first oncolytic virus to gain approval in a Western jurisdiction
Innate immune memory: a paradigm shift in understanding host defense
Monday, 06.22.2015, 06:33am
Researchers gathered at the Wellcome Trust Genome Campus in Hinxton, Cambridge, for the first Innate Immune Memory Conference dedicated to the adaptive characteristics of innate immunity, to further the understanding of this newly described immunological process that probably has a central role in host defense and inflammation.
A formidable challenge
Wednesday, 05.20.2015, 09:13pm
Better understanding of HIV biology, virus-host interactions and mechanisms of an efficient immune response advance efforts for effective vaccines and immunotherapies.
  » Linking primary and metastatic tumour re-initiation
  » Cancer: Antibodies regulate antitumour immunity
  » Brainless immunity no more
  » Homeostatic regulation of T cell trafficking by a B cell–derived peptide is impaired in autoimmune and chronic inflammatory disease
  » RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
  » A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
  » B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
  » B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
  » IL-17–targeting biologics aim to become standard of care in psoriasis
  » Stop the executioners


 
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::| Hot News
Stem cells in the limelight
The genomic landscape of adult T cell leukemia/lymphoma
Reversed-polarity Treg cell TCRs provide a shock
Reversed-polarity Treg cell TCRs provide a shock
Subversion of anticancer immunosurveillance by radiotherapy
[Report] Genomic correlates of response to CTLA4 blockade in metastatic melanoma
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
CD8+ T cell diversification by asymmetric cell division
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
DPP4 in anti-tumor immunity: going beyond the enzyme