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Brain and Neuron Development
Huntington's disease is a four-repeat tauopathy with tau nuclear rods
Tuesday, 07.22.2014, 10:21pm
Tau pathology is identified in brains of individuals with Huntington's disease (HD), and reduction of tau expression can ameliorate disease in HD model mice.
Schizophrenia: Genesis of a complex disease
Tuesday, 07.22.2014, 10:21pm
The largest genome-wide analysis of schizophrenia performed so far has identified more than 100 genetic regions that contribute to disease risk, establishing new leads for understanding this form of mental illness.
Neural stem cell quiescence comes to an un-sticky end
Wednesday, 07.16.2014, 10:53am
Cell–cell interactions, a key feature of the stem cell niche, regulate many aspects of stem cell behaviour. N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.
Wrong place, wrong time: ectopic progenitors cause cortical heterotopias
Monday, 07.14.2014, 02:28pm
A report reveals that giant subcortical heterotopia is caused by mutation of a microtubule-associated protein, Eml1. Defects in Eml1 lead to disruption of the radial migratory scaffolding network in mice and humans.
Shedding light on learning
Friday, 05.30.2014, 03:33pm
Brain-computer interfaces (BCIs) and optical imaging have both undergone impressive technological growth in recent years. A study in which mice learn to modulate neural activity merges these technologies to investigate the neural basis of BCI learning with unprecedented spatial detail.
Amygdala interneuron subtypes control fear learning through disinhibition
Tuesday, 05.13.2014, 09:03am
Plasticity within neuronal microcircuits is believed to be the substrate of learning, and this study identifies two distinct disinhibitory mechanisms involving interactions between PV+ and SOM+ interneurons that dynamically regulate principal neuron activity in the amygdala and thereby control auditory fear learning.
  » TDP2 keeps the brain healthy
  » Deep brain optical measurements of cell type–specific neural activity in behaving mice
  » Deep brain optical measurements of cell type–specific neural activity in behaving mice
  » REDD1 is essential for stress-induced synaptic loss and depressive behavior
  » [Research Article] Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
  » Useful dynamic regimes emerge in recurrent networks
  » Visualizing presynaptic function
  » 10,000 hours to perfection
  » 10,000 hours to perfection

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::| Hot News
Confidence and certainty: distinct probabilistic quantities for different goals
Conceptual and technical advances define a key moment for theoretical neuroscience
Points of View: Neural circuit diagrams
Neurodevelopment: Regeneration switch is a gas
The peptidergic control circuit for sighing
Natural killers in the brain's nursery
Parkinson's disease: Disorder in the court
Bioresorbable silicon electronic sensors for the brain
Back to the past in schizophrenia genomics
Back to the past in schizophrenia genomics