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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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News Release from Allele and Associated Organizations
 
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Thursday, 05.15.2014, 12:19pm (GMT-7)

“Cardiomyocytes generated from induced pluripotent cells (iPSCs) hold great promise for understanding and treating heart disease. William Pu and his colleagues apply new technologies for studying such cardiomyocytes from patients with Barth syndrome to explore how the mitochondrial defects characteristic of this syndrome lead to heart dysfunction.” Stated by Nature Medicine about a new article published in the journal online recently (link to the Nature Medicine online article).

Dr. Jiwu Wang at Allele Biotechnology & Pharmaceuticals, Inc. is a co-author of the paper.  “The Allele Biotech team is excited to see our mRNA-iPSCs performed well in cardiomyocyte generation and helped with this outstanding study”, said Dr. Wang, who is also a professor and the scientific director at the newly formed Scintillon Institute.  Because iPSCs created using only the mRNA molecules do not have DNA inserts in their chromosomes, and tend to have less chromosomal alterations going through the reprogramming process in general, they have better potential for clinical applications than those made with DNA vectors or viral-based carriers.

Allele Biotech, a San Diego-based private technology development company, has provided reprogramming technology and human iPSCs to other companies that are planning on iPSC-derived cell therapies.  Allele Biotech is constructing a dedicated cGMP facility in order to supply FDA-approved iPSCs to their partners.  It also has goals in establishing a path towards autologous iPSC service and banking.

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Other Articles:
New inhibitory signaling by CTLA-4 (04.30.2014)
Join Us Next Thursday for-- Get to Know Your Neighbors (04.14.2014)
The Beginning of a New Era of Antibodies--Allele Biotech Upgrades Trap to nAb (10.30.2013)
Allele Biotech Receives NIH Grant to Further Develop mRNA Reprogramming Kits (06.26.2013)
Allele Biotech Seminar at UCR Dept of Chem Tomorrow (06.12.2013)
Allele Publishes mNeonGreen as the Brightest Monomeric Fluorescent Protein for Super-resolution Imaging (03.30.2013)
Allele Biotechnology Initiates Project On Scaled Manufacturing Of Induced Pluripotent Stem Cells And Differentiation (01.16.2013)
Allele Biotechnology Announces New advance in production of human stem cells (09.15.2012)
SDEE Quarterly Event: Serial Entrepreneurship--Success and Failure (06.06.2011)
Cheap fluorescent microscope for M. tuberculosis detection (03.29.2011)



 
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High quality histologic services are crucial for determining study outcomes. http://www.allelebiotech.com/histology/

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