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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Confidence and certainty: distinct probabilistic quantities for different goals
Thursday, 03.24.2016, 06:08am

The authors use recent probabilistic theories of neural computation to argue that confidence and certainty are not identical concepts. They propose precise mathematical definitions for both of these concepts and discuss putative neural representations.

 

Subverting misconceptions about radiation therapy
Thursday, 03.24.2016, 06:08am
Evidence is emerging that local radiation therapy can convert a tumor into an individualized cancer vaccine in a setting of otherwise ineffective immunotherapy and can work in concert with immunotherapy to control the primary tumor and metastasis outside the radiation field.
EMPIAR: a public archive for raw electron microscopy image data
Wednesday, 03.23.2016, 05:06am
Recent advances in cryo-EM—for example, the development of direct-electron detectors—have led to a sharp increase in the number of 3D EM structures determined to high resolution.
Using goal-driven deep learning models to understand sensory cortex
Wednesday, 03.23.2016, 05:06am
Recent computational neuroscience developments have used deep neural networks to model neural responses in higher visual areas. This Perspective describes key algorithmic underpinnings in computer vision and artificial intelligence that have contributed to this progress and outlines how deep networks could drive future improvements in understanding sensory cortical processing.
R-process enrichment from a single event in an ancient dwarf galaxy
Tuesday, 03.22.2016, 06:00am
Elements heavier than zinc are synthesized through the rapid (r) and slow (s) neutron-capture processes. This implies that a single, rare event produced the r-process material in Reticulum II. The r-process yield and event rate are incompatible with the source being ordinary core-collapse supernovae, but consistent with other possible sources, such as neutron star mergers.
Enabling direct fate conversion with network biology
Tuesday, 03.22.2016, 06:00am
Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.
Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes
Tuesday, 03.22.2016, 06:00am
Analysis of SLOS patient-derived iPSCs reveals that cellular accumulation of the cholesterol precursor 7DHC, rather than cholesterol deficiency, causes dysregulation of Wnt/β-catenin signaling and aberrant neural differentiation.
  » Building functional networks of spiking model neurons
  » High-density three-dimensional localization microscopy across large volumes
  » Conceptual and technical advances define a key moment for theoretical neuroscience
  » A saposin-lipoprotein nanoparticle system for membrane proteins
  » Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
  » Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury
  » A saposin-lipoprotein nanoparticle system for membrane proteins
  » Inferring causal molecular networks: empirical assessment through a community-based effort
  » Conceptual and technical advances define a key moment for theoretical neuroscience
  » Biomedicine: Visionary stem-cell therapies


 
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High quality histologic services are crucial for determining study outcomes. http://www.allelebiotech.com/histology/

::| Hot News
Confidence and certainty: distinct probabilistic quantities for different goals
EMPIAR: a public archive for raw electron microscopy image data
Enabling direct fate conversion with network biology
High-density three-dimensional localization microscopy across large volumes
A saposin-lipoprotein nanoparticle system for membrane proteins
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
A saposin-lipoprotein nanoparticle system for membrane proteins
Conceptual and technical advances define a key moment for theoretical neuroscience
Points of View: Neural circuit diagrams
Stem cells in the limelight