We introduce a technique for measuring the conductivity of individual hybrid metal, semiconducting core-shell and full-metal conducting particles by a microscopic four-point probe (μ-4PP) method. The four-point probe geometry allows for minimizing contact resistances between electrodes and particles. By using a focused ion beam we fabricate platinum nanoleads between four microelectrodes on a silicon chip and an individual particle, and determine the particle's conductivity via sensitive current and voltage measurements. Up to sixteen particles can be taken up by each chip, which allows for multiple conductivity measurements by simply multiplexing the electric contacts connected to a multimeter. Although, for demonstration, we used full Au (conducting) and Ag-coated latex particles (semiconducting) of a few micrometers in diameter, the method can be applied to other types of conducting or semiconducting particles of different diameters.

The new manager will coordinate and manage the operational functions related to grants and contracts of Career and Technical Education (CTE) Biotechnology HUB, and biotechnology center.

Resident T cells are oligoclonal with diverse usage of TCR variable-β genes, which differ from those commonly described for mucosa-associated invariant T cells and natural killer T cells.

The capability of full-sized llama antibodies played out in a project conducted by Eli Lilly. The llama platform generated more than a dozen unique antibodies, all hitting the desired epitope, whereas Lilly's in-house mouse platforms and phage libraries failed to come up with a single suitable antibody.

Algorithms that account for and overcome the intrinsic pixel-dependent readout noise from scientific complementary metal-oxide semiconductor (sCMOS) cameras prevent localization artifacts and avoid substantial compromises in localization uncertainty in single-molecule imaging. When combined with multi-emitter fitting, sCMOS cameras allow video-rate single-molecule switching nanoscopy.

Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer.

Pencheva and Tavazoie discuss the recent advances in understanding how microRNAs control metastatic progression in cancer.

Photoactivable green fluorescent protein (PAGFP) was used to track movement across intercellular canals.  Ring canals ensure that the haves share with their have-not neighbors.Authors: Peter F. McLean, Lynn Cooley

After the knock-out (KO) of α1,3 galactosyltransfease (Gal-T), the Hanganutziu-Deicher antigen became a major antigen of the "non-Gal antigen" that is implicated in subsequent xenograft rejection. For deletion of non-Gal antigen, we successfully produced zinc finger nuclease (ZFN)-mediated monoallelic/biallelic male and female CMP-N-acetylneuraminic acid hydroxylase (CMAH) KO miniature pigs: the efficiency of the gene targeting (41.7%) was higher when donor DNA was used with the ZFN than those of ZFN alone (9.1%). Monoallelic KO pigs had no integration of exogenous DNA into their genome, indicating that this technique would provide a new avenue to reduce the risk of antibiotics resistance when organs from genetically modified pigs are transplanted into patients. Until now, both monoallelic and biallelic CMAH KO pigs are healthy and show no sign of abnormality and off-target mutations. Therefore, these CMAH null pigs on the Gal-T KO background could serve as an important model for the xenotransplantation.

There will also be an exciting drug discovery panel representing elite local companies with drugs that have recently gained FDA approvals to showcase San Diego's drug discovery success stories. The program is guaranteed to generate sizzling discussion, stimulate new ideas, and fuel renewed enthusiasm of investing in San Diego biotech industry.

A new synthetic type of biofuel created by mixing and matching bits of DNA from different organisms could one day replace diesel and jet fuel

Allele's CEO Dr. Jiwu Wang gave a seminar at UCR Department of Chemistry tomorrow at noon, host Prof Huiwang Ai, "mRNA-iPSC, Nanobodies, and the Brightest Monomeric Fluorescent Protein--from a perspective of doing excellent research in a small business setting".