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GET TO KNOW YOUR NEIGHBOR ; SDEE 2015 Year End Social on Dec 8th in San Diego ; Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells ; SDEE October 2015 Event - Financings: Tales from the Tranches ; Allele Biotech Takes Major Step into Nano Antibody Leadership Position
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Confidence and certainty: distinct probabilistic quantities for different goals
Thursday, 03.24.2016, 06:08am

The authors use recent probabilistic theories of neural computation to argue that confidence and certainty are not identical concepts. They propose precise mathematical definitions for both of these concepts and discuss putative neural representations.

EMPIAR: a public archive for raw electron microscopy image data    Enabling direct fate conversion with network biology
 
 
All science fields
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Subverting misconceptions about radiation therapy
Thursday, 03.24.2016, 06:08am
Evidence is emerging that local radiation therapy can convert a tumor into an individualized cancer vaccine in a setting of otherwise ineffective immunotherapy and can work in concert with immunotherapy to control the primary tumor and metastasis outside the radiation field.
Using goal-driven deep learning models to understand sensory cortex
R-process enrichment from a single event in an ancient dwarf galaxy
   
News Release from Allele and Associated Organizations
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GET TO KNOW YOUR NEIGHBOR
Tuesday, 02.09.2016, 11:32pm

Join us for a networking event to help find collaborators, vendors, customers, advisers and investors, jobs, employees and meet your fellow entrepreneurs in your own neighborhood. Attendance is free! 

SDEE 2015 Year End Social on Dec 8th in San Diego
Must Attend 5-Day Event in San Diego Starting Tomorrow! -- CDW on Cells, Sensors, and Sysems, with Updates on Stem Cells
Using single cell technologies for functional studies
More ++
Highly multiplexed simultaneous detection of RNAs and proteins in single cells
Tuesday, 02.09.2016, 01:30am
PLAYR (proximity ligation assay for RNA) enables highly multiplexed transcript quantification in combination with protein marker detection in single cells using flow or mass cytometry.
Gene regulation: Expression feels two pulses
Gene regulation: Expression feels two pulses
   
Job Postings/Lab Visits/Vendor Shows
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Laboratory, Research/ Development
Saturday, 10.17.2015, 11:11pm

The individual will assist in day-to-day laboratory operations under the direct supervision of the lab manager. Duties will include the full scope of basic lab activities: prepare buffers/media, measuring samples, assemble PCR reactions, run machines. Individual will also be involved in assisting with more advanced lab techniques such as: protein expression, protein purification and phage display.

Postdoc Research Associate – Stem Cells
Grants and general administrator for the Scintillon Institute.
Imaging, Structure, and Optogenetics
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High-density three-dimensional localization microscopy across large volumes
Friday, 03.18.2016, 09:44pm
Lattice light-sheet and PAINT microscopy are combined to achieve low-background detection of dense molecular labels, yielding super-resolution localization microscopy images of intricate 3D structures within dividing cells and embryos.
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
A saposin-lipoprotein nanoparticle system for membrane proteins
   
Brain and Neuron Development
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Conceptual and technical advances define a key moment for theoretical neuroscience
Friday, 03.11.2016, 10:48pm
Theoretical approaches have long shaped neuroscience, but current needs for theory are elevated and prospects for advancement are bright. Advances in measuring and manipulating neurons demand new models and analyses to guide interpretation. 
Points of View: Neural circuit diagrams
Neurodevelopment: Regeneration switch is a gas
Camelid Antibodies
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Dpp spreading is required for medial but not for lateral wing disc growth
Tuesday, 11.10.2015, 11:40am
The morphogen Decapentaplegic (Dpp) has been implicated in both wing patterning and growth in fruitflies; here, a nanobody-based morphotrap approach has been developed that rules out a role for the Dpp gradient in regulating lateral wing growth.
Complementary IMAC enrichment methods for HLA-associated phosphopeptide identification by mass spectrometry
Allele Biotech Takes Major Step into Nano Antibody Leadership Position
   
FP Technologies and In Vivo Imaging
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iSMS: single-molecule FRET microscopy software
Thursday, 07.23.2015, 09:33pm
Here we present iSMS: an interactive toolkit for the comprehensive analysis of smFRET TIRF-microscopy data
High photon flux table-top coherent extreme-ultraviolet source
[Research Article] Extensive remodeling of a cyanobacterial photosynthetic apparatus in far-red light
iPSC MSC ESC Differentiation
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Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes
Tuesday, 03.22.2016, 06:00am
Analysis of SLOS patient-derived iPSCs reveals that cellular accumulation of the cholesterol precursor 7DHC, rather than cholesterol deficiency, causes dysregulation of Wnt/β-catenin signaling and aberrant neural differentiation.
Biomedicine: Visionary stem-cell therapies
Stem cells in the limelight
   
Immune systems, T cell Therapy, stem cell therapy
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Stem cells in the limelight
Saturday, 03.05.2016, 03:04am
Stem cell biology has emerged as one of the most exciting areas of basic and biomedical research. This month, we launch a series of specially commissioned articles that discuss recent advances and challenges in this field.
Reflections on immunological nomenclature: in praise of imperfection
Decoding the immune response to successful influenza vaccination
RNA, RNAi, and miRNA Updates
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Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Wednesday, 01.06.2016, 11:40am
This virus-free approach for mRNA knockdown in vivo uses the siRNA carrier peptide protamine, chemically coupled to a cell surface receptor internalizing antibodies via sulfo-SMCC, to provide protection and guidance for the targeted application of siRNA.
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
   
NexGen Sequencing, Epigenetics, and Editing
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Analysis of five years of controlled access and data sharing compliance at the International Cancer Genome Consortium
Friday, 03.04.2016, 01:02am
Questions have been raised about whether these data sharing practices carry potential privacy risks for research participants
Analysis of computational footprinting methods for DNase sequencing experiments
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
News Release from Other Organizations
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SDEE Workshop Alliance Roadmaps: Navigating the process to obtain and build winning partnerships
Saturday, 10.17.2015, 11:15pm

Thursday November 12, 2015 5:30-8:30pm

Location: Hera Hub 4010 Sorrento Valley Rd, San Diego, CA 92121

What You Need To Know About Term Sheets for Early Stage Financing and Partnering Intensive Workshop for Entrepreneurs
Immunology careers at the NIH, FDA and CDC: different paths that focus on advancing public health
   
 
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High quality histologic services are crucial for determining study outcomes. http://www.allelebiotech.com/histology/

::| Hot News
High-density three-dimensional localization microscopy across large volumes
A saposin-lipoprotein nanoparticle system for membrane proteins
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
A saposin-lipoprotein nanoparticle system for membrane proteins
Conceptual and technical advances define a key moment for theoretical neuroscience
Points of View: Neural circuit diagrams
Stem cells in the limelight
Analysis of five years of controlled access and data sharing compliance at the International Cancer Genome Consortium
Neurodevelopment: Regeneration switch is a gas
Analysis of computational footprinting methods for DNase sequencing experiments